Lysophosphatidic Acid Signaling Protects Pulmonary Vasculature From Hypoxia-Induced Remodeling
نویسندگان
چکیده
منابع مشابه
Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling.
OBJECTIVE Lysophosphatidic acid (LPA) is a bioactive lipid molecule produced by the plasma lysophospholipase D enzyme autotaxin that is present at ≥100 nmol/L in plasma. Local administration of LPA promotes systemic arterial remodeling in rodents. To determine whether LPA contributes to remodeling of the pulmonary vasculature, we examined responses in mice with alterations in LPA signaling and ...
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This debate focuses on whether, and to what extent, loss of small precapillary arteries is associated with the elevation in pulmonary artery pressure and resistance that accompanies chronic hypoxia-induced pulmonary hypertension. The issue has become the focus of much debate for a number of reasons. Papers from McLoughlin and his group (5, 6) have provided conclusive evidence that there is cons...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2012
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.111.234708